Endogenous endothelin-1 and femoral artery shear rate
نویسندگان
چکیده
منابع مشابه
Superficial Femoral Artery Endothelial Responses to a Short-Term Altered Shear Rate Intervention in Healthy Men
In animal and in-vitro models, increased oscillatory shear stress characterized by increased retrograde shear-rate (SR) is associated with acutely decreased endothelial cell function. While previous research suggests a possible detrimental role of elevated retrograde SR on endothelial-function in the brachial artery in humans, little research has been conducted examining arteries in the leg. Ex...
متن کاملManipulation of arterial stiffness, wave reflections, and retrograde shear rate in the femoral artery using lower limb external compression
Exposure of the arterial wall to retrograde shear acutely leads to endothelial dysfunction and chronically contributes to a proatherogenic vascular phenotype. Arterial stiffness and increased pressure from wave reflections are known arbiters of blood flow in the systemic circulation and each related to atherosclerosis. Using distal external compression of the calf to increase upstream retrograd...
متن کاملAcute impact of retrograde shear rate on brachial and superficial femoral artery flow‐mediated dilation in humans
Retrograde shear rate (SR) in the brachial artery (BA) is associated with endothelial dysfunction; a precursor to atherosclerosis. The BA does not typically manifest clinical atherosclerosis, whereas the superficial femoral artery (SFA) is more prone to developing plaque. Examine whether the impact of incremental levels of retrograde SR differs between atherosclerosis-prone (i.e., SFA) and -res...
متن کاملImpact of age and body position on the contribution of nitric oxide to femoral artery shear rate: implications for atherosclerosis.
Reduced shear stress and augmented oscillatory shear rate are associated with the proatherogenic phenotype observed with aging. To date, mechanisms contributing to the age-related alterations in shear rate in humans have only been examined in the conduit vessels of the arm. Therefore, this study sought to examine the contribution of nitric oxide (NO) bioavailability to age-related alterations i...
متن کاملEndogenous endothelin-1 is required for cardiomyocyte survival in vivo.
BACKGROUND Endothelin-1 (ET-1) has potent vasoconstrictor and hypertrophic actions. Pharmacological antagonists of endothelin receptors attenuate cardiac hypertrophy, have been approved for treatment of pulmonary hypertension, and are under investigation for treatment of heart failure. To investigate the role of ET-1 in the heart, we created mice with cardiomyocyte deletion of ET-1. METHODS A...
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ژورنال
عنوان ژورنال: Journal of Hypertension
سال: 2016
ISSN: 0263-6352
DOI: 10.1097/hjh.0000000000000777